Mint Districts Wellness

Longevity and Biohacking Supplement Brands Built on Actual Research

The longevity supplement market exploded alongside the popularization of researchers like David Sinclair and Valter Longo, and the result is a chaotic mix of serious science-backed brands and opportunists who learned to say NAD+ and senolytic in a sentence. The brands worth paying attention to share a few things: published research citations rather than vague studies-show language, transparent sourcing, third-party testing, and a willingness to make specific claims that can actually be evaluated. This district is the serious end of that spectrum , brands building real products around aging biology, not just wellness aesthetics.

Wellness · 6 Brands

The Longevity District

Momentous

San Diego, CA

NSF-certified longevity and performance supplements for serious athletes and researchers.

Momentous built credibility in elite sports by becoming one of the few supplement brands with full NSF Certified for Sport certification across their lineup. Andrew Huberman, Peter Attia, and dozens of professional sports teams use them. The longevity stack reflects protocols from the research community rather than marketing , and the third-party certification makes that claim verifiable.

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Neurogan Health

San Diego, CA

Research-backed longevity compounds with third-party COAs on every product.

Neurogan developed serious third-party testing infrastructure before expanding from hemp supplements into longevity compounds. Every product has a publicly accessible certificate of analysis. Their NMN capsules and GHK-Cu peptide products have become reference products in the biohacking community for buyers who want verification, not trust.

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Elysium Health

New York, NY

Longevity supplements co-developed with Nobel laureate advisors and human trial data.

Elysium was co-founded with input from multiple Nobel Prize-winning scientists and is one of the few supplement companies running actual human clinical trials on their own products. Their flagship, Basis (NR and pterostilbene), has been studied in trials measuring NAD+ levels directly , rare in a category full of extrapolation from animal studies.

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Renue by Science

Charlotte, NC

High-bioavailability NMN formulations built for better absorption.

Renue by Science built their reputation around a real problem: oral NMN gets partially broken down in digestion before reaching the bloodstream. Their sublingual and liposomal delivery formats address bioavailability directly. Andrew Huberman mentions them when discussing NAD+ precursors, and the brand's focus on delivery method over marketing sets them apart.

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Tru Niagen

Irvine, CA

Patented nicotinamide riboside with 25+ completed human clinical trials.

Tru Niagen is the consumer brand for ChromaDex's NIAGEN NR , the most studied form of NR available, with peer-reviewed research published in Nature Communications and Cell Metabolism. The science is unusually solid for a supplement category: human trials, not animal extrapolation, and the intellectual property is patented rather than generically sourced.

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ProLon

Los Angeles, CA

The 5-day fasting-mimicking diet developed in Valter Longo's longevity lab at USC.

ProLon is the commercial product of 20 years of research in Valter Longo's lab at USC. The five-day program puts the body in a fasted metabolic state while still eating , triggering autophagy and cellular renewal. Human trials have shown measurable reductions in biological age markers and visceral fat after multiple quarterly cycles. It's not a supplement stack. It's a validated protocol.

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About This District

The longevity supplement category is complicated by unresolved science. Here's a practical framework for what's worth taking and which brands to trust. NAD+ precursors (NMN and NR) are the highest-signal category. Both support NAD+ production, which declines with age and plays a central role in cellular energy and DNA repair. Tru Niagen uses patented NR with over 25 human clinical trials behind the ingredient. Renue by Science focuses on bioavailability via sublingual and liposomal delivery. Momentous uses quality standards comparable to their NSF-certified sports line. Senolytics , compounds that target senescent cells , include fisetin and quercetin. The research is early but compelling. Neurogan Health has products in this category with published COAs. Elysium includes pterostilbene alongside NR in their flagship Basis formulation. Fasting mimetics are represented by ProLon , a five-day fasting-mimicking diet protocol developed by Valter Longo's lab at USC. It's one of the most rigorously studied longevity interventions in the category, with human trials showing measurable reductions in biological age markers. Third-party testing is non-negotiable. Look for NSF Certified for Sport, Informed Sport, or USP verification. Momentous is NSF certified across their lineup , the highest bar in the industry. Thorne uses USP standards in manufacturing. Neurogan publishes public certificates of analysis for every product. Avoid proprietary blends that hide ingredient dosages, vague claims without citations, and brands that don't publish ingredient sourcing. The longevity space has more marketing than rigor. These brands are the exceptions.